Preparation and Properties of Polylactic Acid/Polyesteramide Composite Nanofiber Film
Cui Xinxiang, Wang Yanhe, Han Libin, Sun Qihao, Song Xiaofeng
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, China
Abstract：Biodegradable P-(CL-EA-CL) polyesteramide containing L-alanine, ethylene glycol, and caprolactone in the main chain was synthesized by solution polymerization and chain extension methods. The synthetic product was confirmed by FTIR and 1H NMR. The PLLA/P-(CL-EA-CL) composite nanofiber membrane was prepared by blending it with poly-L-lacticacid (PLLA) for electrospinning. The effects of different blending ratios and graft ratios on the fiber membrane were explored. The results showed that the addition of P-(CL-EA-CL) polyesteramide improved the mechanical properties of the fiber membrane, and the hydrophilicity of the fiber membrane was also significantly improved. When the P-(CL-EA-CL) content was 30% and the graft ratio was 1∶4, the tensile strength of the blended film was 11.43 MPa, the elongation at break was 56.21%, and the hydrophilic angle decreased from 138.2° of pure PLLA fiber membrane to 76.3°. Degradation experiments in different environments also found that the blended fiber membrane had alkaline degradation sensitivity. Cytotoxicity tests further characterized the good biocompatibility of the blended membranes. Therefore, PLLA/P-(CL-EA-CL) composite nanofiber membrane has application potential in the field of biological tissue engineering.
Keywords：polyesteramide; L-alanine; caprolactone; chain extension; PLLA; composite nanofiber membrane
Cui Xinxiang，Wang Yanhe，Han Libin，et al. Preparation and properties of polylactic acid/polyesteramide composite nanofiber film[J]. Engineering Plastics Application，2020，48(3)：14-21.