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《工程塑料应用》 2020年第03期
DOI:10.3969/j.issn.1001-3539.2020.03.003
聚乳酸/聚酯酰胺复合纳米纤维膜制备及性能
崔心想,王艳贺,韩立彬,孙奇浩,宋晓峰
长春工业大学化学工程学院,吉林长春 130012 
Preparation and Properties of Polylactic Acid/Polyesteramide Composite Nanofiber Film
Cui Xinxiang, Wang Yanhe, Han Libin, Sun Qihao, Song Xiaofeng
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, China 
摘要:通过溶液聚合和扩链方法合成了主链中含有L-丙氨酸、乙二醇、己内酯的生物可降解聚酯酰胺[P-(CL-EA-CL)],采用红外光谱、核磁共振光谱证明产物合成。将其与左旋聚乳酸(PLLA)共混静电纺丝成膜制备了PLLA/P-(CL-EA-CL)复合纳米纤维膜,探究了不同共混比和接枝比对纤维膜的影响。结果表明,加入P-(CL-EA-CL)改善了纤维膜的力学性能,同时纤维膜的亲水性也得到明显改善。当P-(CL-EA-CL)添加量为30%、接枝比例为1∶4时,共混膜的拉伸强度为11.43 MPa,断裂伸长为56.21%,亲水角由纯PLLA纤维膜的138.2°减小到76.3°。在不同环境的降解实验也发现共混纤维膜具有碱性降解敏感性,细胞毒性测试进一步表征共混膜良好的生物相容性,PLLA/P-(CL-EA-CL)复合纳米纤维膜有生物组织工程领域的应用潜力。 
Abstract:Biodegradable P-(CL-EA-CL) polyesteramide containing L-alanine, ethylene glycol, and caprolactone in the main chain was synthesized by solution polymerization and chain extension methods. The synthetic product was confirmed by FTIR and 1H NMR. The PLLA/P-(CL-EA-CL) composite nanofiber membrane was prepared by blending it with poly-L-lacticacid (PLLA) for electrospinning. The effects of different blending ratios and graft ratios on the fiber membrane were explored. The results showed that the addition of P-(CL-EA-CL) polyesteramide improved the mechanical properties of the fiber membrane, and the hydrophilicity of the fiber membrane was also significantly improved. When the P-(CL-EA-CL) content was 30% and the graft ratio was 1∶4, the tensile strength of the blended film was 11.43 MPa, the elongation at break was 56.21%, and the hydrophilic angle decreased from 138.2° of pure PLLA fiber membrane to 76.3°. Degradation experiments in different environments also found that the blended fiber membrane had alkaline degradation sensitivity. Cytotoxicity tests further characterized the good biocompatibility of the blended membranes. Therefore, PLLA/P-(CL-EA-CL) composite nanofiber membrane has application potential in the field of biological tissue engineering. 
关键词:聚酯酰胺;L-丙氨酸;己内酯;扩链;左旋聚乳酸;复合纳米纤维膜 
Keywords:polyesteramide; L-alanine; caprolactone; chain extension; PLLA; composite nanofiber membrane 
本文引用格式:
崔心想,王艳贺,韩立彬,等.聚乳酸/聚酯酰胺复合纳米纤维膜制备及性能[J].工程塑料应用,2020,48(3):14-21.
Cui Xinxiang,Wang Yanhe,Han Libin,et al. Preparation and properties of polylactic acid/polyesteramide composite nanofiber film[J]. Engineering Plastics Application,2020,48(3):14-21. 

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