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《工程塑料应用》 2021年第10期
DOI:10.3969/j.issn.1001-3539.2021.10.002
基于层层自组装多层膜的耐用性超滑导管制备
程静1,陈苏仰1,孙文文2,姚天平3,尧婉辰4,曾冬冬1,林祥德1
1.上海健康医学院医疗器械学院,上海 201318; 2.上海健康医学院医学技术学院,上海 201318; 3.上海市医疗器械检验研究院,上海201318; 4.上海理工大学医疗器械与食品学院,上海 200093 
Robust Lubricant-Infused Slippery Medical Catheters Based on Layer-by-Layer Assembled Multilayers
Cheng Jing1, Chen Suyang1, Sun Wenwen2, Yao Tianping3, Yao Wanchen4, Zeng Dongdong1, Lin Xiangde1
1. School of Medical Instrument, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China; 2. School of Medical Technology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China; 3. Shanghai Inspection and Testing Institute for Medical Devices, Shanghai 201318, China; 4. School of Medical Instrumentation and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China 
摘要:利用支化聚乙烯亚胺(BPEI)和二氧化硅纳米颗粒-倍半硅氧烷(SiSQ)之间的氢键相互作用,通过层层自组装交替沉积技术分别在硅片和医用导管表面制备了基于40 nm和80 nm二氧化硅纳米颗粒的(BPEI/SiSQ)n多孔多层膜,并通过低黏度硅油多孔灌注的方法制备了ST/(BPEI/SiSQ)n-SO超滑硅胶导管。利用扫描电子显微镜对二氧化硅纳米颗粒和层层自组装多层膜分别进行形貌表征,通过傅里叶变换红外光谱对不同样品进行化学成分分析,证明了(BPEI/SiSQ)n 和(BPEI/SiSQ)n-SO涂层的成功制备。另外,以硅片为基底的Si/(BPEI/SiSQ)n-SO水滴接触角和滑动角测量数据分别为104°和4°左右,表明其具有良好的超滑性能。对ST/(BPEI/SiSQ)n-SO超滑导管进行了稳健性测试,包括机械性、化学腐蚀和抗污染测试,展现了稳定的超滑性能。 
Abstract:Herein, hydrogen boning interaction between branched polyethyleneimine (BPEI) and silica nanoparticle-silsesquioxane matrix (SiSQ) has been used as the driving force for assembling porous layer-by-layer multilayers on silicon wafer and medical catheter substrates, using 40 nm or 80 nm silica nanoparticles as building blocks. Then, slippery ST/(BPEI/SiSQ)n-SO catheters were prepared by infusing silicone oil with low viscosity into porous ST/(BPEI/SiSQ)n. In the present work, the surface morphology for silica nanoparticles and layer-by-layer assembled multilayers was characterized by scanning electron microscopy (SEM) while chemical analysis was conducted by Fourier transform infrared spectroscopy (FTIR), which indicates successful preparation of (BPEI/SiSQ)n and (BPEI/SiSQ)n-SO coatings. In addition, water contact angle and sliding angle are about 104° and 4°, which are measured on Si/(BPEI/SiSQ)n-SO based on silicon wafer substrate, indicating a good slippery property. At last, the robustness of slippery ST/(BPEI/SiSQ)n-SO catheters was examined, involving mechanical damage, chemical corrosion, and fouling tests. Therefore, an excellent slippery performance is demonstrated on ST/(BPEI/SiSQ)n-SO catheters. 
关键词:医用导管;层层自组装;液体灌注超滑表面;耐用性 
Keywords:medical catheter; layer-by-layer assembly; lubricant-infused slippery surface; robustness 
基金:国家自然科学基金项目(22008151),上海健康医学院高水平地方高校建设项目(E1-2602-21-201006-1),上海健康医学院科研骨干学术导师制项目(E3-0200-21-201012-8) 
本文引用格式:
程静,陈苏仰,孙文文,等.基于层层自组装多层膜的耐用性超滑导管制备[J].工程塑料应用,2021,49(10):6-11.
Cheng Jing,Chen Suyang,Sun Wenwen,et al. Robust lubricant-infused slippery medical catheters based on layer-by-layer assembled multilayers[J]. Engineering Plastics Application,2021,49(10):6-11. 

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